Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion

Binghui Jin; Guangyao Li; Lin Zhou; Zhe Fan

doi:10.3389/fphar.2022.924695

Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion

Front Pharmacol. 2022 May 23:13:924695. doi: 10.3389/fphar.2022.924695. eCollection 2022.

Authors

Binghui Jin^{1

2}, Guangyao Li^{1

2}, Lin Zhou³, Zhe Fan^{1

2}

Affiliations

¹ Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.
² Department of Central Laboratory, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, China.
³ Department of Outpatient, the NO. 967 Hospital of PLA Joint Logistics Support Force, Dalian Medical University, Dalian, China.

Abstract

Intestinal ischemia-reperfusion (I/R) is a common pathophysiological process, which can occur in many conditions such as acute enteric ischemia, severe burns, small intestinal transplantation, etc,. Ischemia-reperfusion of the intestine is often accompanied by distal organ injury, especially liver injury. This paper outlined the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R: the NF-κB Signaling Pathway, the P66shc Signaling Pathway, the HMGB1 Signaling Pathway, the Nrf2-ARE Signaling Pathway, the AMPK-SIRT-1 Signaling Pathway and other cytokines, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.

Keywords: acute liver injury; intestinal ischemia-reperfusion; mechanism; signal transduction pathways; treatment.

Publication types

Review