Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment

Ping Tan; Ming Shi; Li Lai; Zhuang Tang; Nan Xie; Hang Xu; Qiang Wei; Xiaoyu Zhang; Lu Yang; Lily Wu

doi:10.1093/pcmedi/pby006

Regulative role of the CXCL13-CXCR5 axis in the tumor microenvironment

Precis Clin Med. 2018 Jun;1(1):49-56. doi: 10.1093/pcmedi/pby006. Epub 2018 Jun 12.

Authors

Ping Tan¹, Ming Shi¹, Li Lai², Zhuang Tang¹, Nan Xie³, Hang Xu¹, Qiang Wei¹, Xiaoyu Zhang⁴, Lu Yang¹, Lily Wu^{4

5}

Affiliations

¹ Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan.
² The Center of Anesthesiology and Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan.
³ Department of Emergency, West China Hospital, Sichuan University, Chengdu, Sichuan.
⁴ Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
⁵ Department of Urology, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Abstract

Chemokines are best known for their abilities of recruiting immune cells and forming lymphoid tissue. Through interactions between chemokines and their receptors, various immune cell subsets are recruited into the tumor microenvironment which is the primary location for tumor cells interacting with responding host cells. In recent decades, a large volume of studies have revealed chemokines' role in the tumor microenvironment in regulating tumor growth, invasion, and/or metastasis as well as tumor immune response; however, their molecular mechanisms are not well understood. Recently, increasing evidence has reported the importance of the CXCL13-CXCR5 axis in the tumor microenvironment of various human malignancies. Thus, in this review, we will focus on the CXCL13-CXCR5 axis and elaborate on the expression patterns, regulating and corresponding regulatory mechanisms as well as clinical values in a wide range of human cancers.

Keywords: CXCL13; CXCR5; chemokine; microenvironment; tumor.

Publication types

Review