Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Shuang Tang; Jie Li; Yung-Fu Chang; Wencheng Lin

doi:10.3389/fimmu.2022.907287

Avian Leucosis Virus-Host Interaction: The Involvement of Host Factors in Viral Replication

Front Immunol. 2022 May 26:13:907287. doi: 10.3389/fimmu.2022.907287. eCollection 2022.

Authors

Shuang Tang¹, Jie Li², Yung-Fu Chang², Wencheng Lin¹

Affiliations

¹ Guangdong Provincial Key Laboratory of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction of Ministry of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, China.
² Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, United States.

Abstract

Avian leukosis virus (ALV) causes various diseases associated with tumor formation and decreased fertility. Moreover, ALV induces severe immunosuppression, increasing susceptibility to other microbial infections and the risk of failure in subsequent vaccination against other diseases. There is growing evidence showing the interaction between ALV and the host. In this review, we will survey the present knowledge of the involvement of host factors in the important molecular events during ALV infection and discuss the futuristic perspectives from this angle.

Keywords: avian leukemia virus; host factors; immunosuppression; interaction; replication.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Avian Leukosis Virus*
Avian Leukosis* / pathology
Chickens
Virus Replication