Identification of Immune Infiltration-Related ceRNAs as Novel Biomarkers for Prognosis of Patients With Primary Open-Angle Glaucoma

Daowei Zhang; Jiawen Wu; Shenghai Zhang; Jihong Wu

doi:10.3389/fgene.2022.838220

Identification of Immune Infiltration-Related ceRNAs as Novel Biomarkers for Prognosis of Patients With Primary Open-Angle Glaucoma

Front Genet. 2022 May 27:13:838220. doi: 10.3389/fgene.2022.838220. eCollection 2022.

Authors

Daowei Zhang¹, Jiawen Wu¹, Shenghai Zhang^{1

2

3

4}, Jihong Wu^{1

2

3

4}

Affiliations

¹ Eye and ENT Hospital, College of Medicine, Eye Institute, Fudan University, Shanghai, China.
² Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China.
³ State Key Laboratory of Medical Neurobiology, Institutes of Brain Science and Collaborative Innovation Center for Brain Science, Shanghai, China.
⁴ Key Laboratory of Myopia, Ministry of Health, Shanghai, China.

Abstract

Glaucoma is the leading cause of irreversible blindness globally; hence, relevant clinical biomarkers are necessary to enable diagnosis, early detection, and development of novel therapies. The differentially expressed genes were annotated and visualized using Gene Ontology and Kyoto Encyclopedia. In addition, a competitive endogenous ribonucleic acids network was constructed using Cytoscape, which explained the regulation of gene expression in glaucoma. The CIBERSORT algorithm was employed to analyze the immune microenvironment. We validated that the core genes could predict glaucoma occurrence and development and identified potential molecular mechanism pathways, which were associated with immune infiltration and participated in endogenous regulation networks. Our data may partially explain the pathogenesis of glaucoma and they provide potential theoretical support for targeted therapy.

Keywords: POAG; ceRNA network; enrichment analysis; glaucoma; trabecular meshwork.