Fatal Balamuthia mandrillaris infection with red plaques on the nasal dorsum as the first presentation

Abstract

Balamuthia mandrillaris infection is a rare infectious disease around the world, with high rates of morbidity and mortality. Its early and correct diagnosis is a big challenge for us, and without it the delay in starting effective treatment can lead to the development of encephalitis. This is a report of a case of Balamuthia mandrillaris infection in a Chinese boy, with red plaques on the nasal dorsum as the first presentation, who finally developed into fatal encephalitis. The authors have reviewed the related literature and share the special skin features in order to favor the early diagnosis of the disease and increase the chances of survival.

Keywords: Amebiasis; Balamuthia mandrillaris; Encephalitis; Granuloma; Skin diseases.