Novel therapeutic avenues for the study of chronic liver disease and regeneration: The foundation of the Iberoamerican Consortium for the study of liver Cirrhosis
Gastroenterol Hepatol. 2023 Apr;46(4):322-328.
doi: 10.1016/j.gastrohep.2022.05.012.
Epub 2022 Jun 7.
[Article in
English,
Spanish]
Authors
Carlos Sanz-Garcia
1
, Yulia A Nevzorova
2
, Eduardo Martínez-Naves
3
, Francisco Javier Cubero
4
; Iberoamerican Consortium for the study of liver Cirrhosis; Alejandro Hionides-Gutierrez
1
, Jose Ramón Sañudo
5
, Carlos Enrich
6
, Carles Rentero
6
, Pau Sancho-Bru
7
, Ricardo U Macías-Rodriguez
8
, Astrid Ruiz-Margain
8
, David Kershenobich-Stalnikowitz
8
, Nestor R Vargas
9
, Alberto E Muñoz
9
, Helder I Nakaya
10
Affiliations
- 1 Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, Madrid, Spain.
- 2 Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain; Department of Internal Medicine III, University Hospital RWTH Aachen, Aachen, Germany.
- 3 Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, Madrid, Spain; 12 de Octubre Health Research Institute (imas12), Madrid, Spain.
- 4 Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain. Electronic address: fcubero@ucm.es.
- 5 Department of Anatomy and Embriology, Complutense University School of Medicine, Madrid, Spain.
- 6 Institut d'Investigacions Biomèdiques August Pi i Sunyer, IDIBAPS Universitat de Barcelona, Barcelona, Spain.
- 7 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer, IDIBAPS Universitat de Barcelona, Barcelona, Spain.
- 8 Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México (UNAM), Mexico City, Mexico.
- 9 Sección Hepatología, Hospital Dr. Carlos Bonorino Udaondo, Facultad de Medicina, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina; Instituto de Investigaciones en Salud Pública, Facultad de Odontología, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.
- 10 Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil.
Abstract
Unfortunately, there is a gap of understanding in the pathophysiology of chronic liver disease due to the lack of experimental models that exactly mimic the human disease. Additionally, the diagnosis of patients is very poor due to the lack of biomarkers than can detect the disease in early stages. Thus, it is of utmost interest the generation of a multidisciplinary consortium from different countries with a direct translation. The present reports the meeting of the 2021 Iberoamerican Consortium for the study of liver Cirrhosis, held online, in October 2021. The meeting, was focused on the recent advancements in the field of chronic liver disease and cirrhosis with a specific focus on cell pathobiology and liver regeneration, molecular and cellular targets involved in non-alcoholic hepatic steatohepatitis, alcoholic liver disease (ALD), both ALD and western diet, and end-stage liver cirrhosis and hepatocellular carcinoma. In addition, the meeting highlighted recent advances in targeted novel technology (-omics) and opening therapeutic avenues in this field of research.
Keywords:
Chronic liver disease; Cirrhosis; Cirrosis; ER stress; Enfermedad hepática crónica; Estrés del retículo endoplásmico; Liver regeneration; OMICs; Regeneración hepática; Ómica.
Copyright © 2022 Elsevier España, S.L.U. All rights reserved.
MeSH terms
-
Humans
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Liver Cirrhosis / etiology
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Liver Diseases, Alcoholic* / therapy
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Liver Neoplasms*
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Non-alcoholic Fatty Liver Disease* / pathology
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Non-alcoholic Fatty Liver Disease* / therapy