Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Margaret A Madigan; Ashim Gupta; Abdalla Bowirrat; David Baron; Rajendra D Badgaiyan; Igor Elman; Catherine A Dennen; Eric R Braverman; Mark S Gold; Kenneth Blum

doi:10.3390/ijerph19116395

Precision Behavioral Management (PBM) and Cognitive Control as a Potential Therapeutic and Prophylactic Modality for Reward Deficiency Syndrome (RDS): Is There Enough Evidence?

Int J Environ Res Public Health. 2022 May 24;19(11):6395. doi: 10.3390/ijerph19116395.

Authors

Margaret A Madigan¹, Ashim Gupta², Abdalla Bowirrat³, David Baron⁴, Rajendra D Badgaiyan⁵, Igor Elman⁶, Catherine A Dennen¹, Eric R Braverman¹, Mark S Gold⁷, Kenneth Blum^{1

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Affiliations

¹ The Kenneth Blum Behavioral & Neurogenetic Institute, LLC., Austin, TX 78701, USA.
² Future Biologics, Lawrenceville, GA 30043, USA.
³ Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel 40700, Israel.
⁴ Center for Psychiatry, Medicine, & Primary Care (Office of Provost), Division of Addiction Research & Education, Western University Health Sciences, Pomona, CA 91766, USA.
⁵ Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX 78229, USA.
⁶ Center for Pain and the Brain (P.A.I.N Group), Department of Anesthesiology, Critical Care & Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
⁷ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
⁸ Institute of Psychology, ELTE Eötvös Loránd University, Egyetem tér 1-3, 1053 Budapest, Hungary.
⁹ Department of Psychiatry, School of Medicine, University of Vermont, Burlington, VT 05405, USA.
¹⁰ Department of Psychiatry, Wright State University Boonshoft School of Medicine, Dayton VA Medical Centre, Dayton, OH 45324, USA.

Abstract

This brief commentary aims to provide an overview of the available and relatively new precision management of reward deficiencies manifested as substance and behavioral disorders. Current and future advances, concepts, and the substantial evidential basis of this potential therapeutic and prophylactic treatment modality are presented. Precision Behavioral Management (PBM), conceptualized initially as Precision Addiction Management (PAM), certainly deserves consideration as an important modality for the treatment of impaired cognitive control in reward processing as manifested in people with neurobiologically expressed Reward Deficiency Syndrome (RDS).

Keywords: Genetic Addiction Risk Severity (GARS) test; Restoregen ®; dopamine; hypodopaminergia; pro-dopamine regulation (KB220).

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Behavior, Addictive* / prevention & control
Behavior, Addictive* / psychology
Cognition
Humans
Reward*
Streptothricins
Syndrome

Substances

phytobacteriomycin
Streptothricins

Abstract

Publication types

MeSH terms

Substances

Grants and funding