Electrospray ionization-tandem mass spectrometric study of fused nitrogen-containing ring systems

Gábor Krajsovszky; Borbála Dalmadiné Kiss; Krisztina Ludányi; István M Mándity; Dóra Bogdán

doi:10.1002/jms.4870

Electrospray ionization-tandem mass spectrometric study of fused nitrogen-containing ring systems

J Mass Spectrom. 2022 Jun;57(6):e4870. doi: 10.1002/jms.4870.

Authors

Gábor Krajsovszky¹, Borbála Dalmadiné Kiss², Krisztina Ludányi², István M Mándity^{1

3}, Dóra Bogdán^{1

3}

Affiliations

¹ Department of Organic Chemistry, Semmelweis University, Budapest, Hungary.
² Department of Pharmaceutics, Semmelweis University, Budapest, Hungary.
³ Artificial Transporters Research Group, Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Budapest, Hungary.

Abstract

Four fused nitrogen-containing ring systems were investigated by electrospray ionization-tandem mass spectrometry: Pyridazino-indoles, pyridazino-quinolines, a pyrimido-quinoline derivative and pyrimido-cinnolines. Fragmentation patterns of these compounds are discussed and compared. Several characteristic cross-ring fragments were formed mainly on the pyridazine and pyrimidine rings of the ring systems. The connected Cl, NO₂ , Me, Ph and more extended heterocyclic substituents influenced the fragmentation.

Keywords: fragmentation; fused N-heterocycles; pyridazino-indoles; pyridazino-quinolines; pyrimido-cinnolines; pyrimido-quinolines; tandem mass spectrometry.

MeSH terms

Nitrogen* / chemistry
Spectrometry, Mass, Electrospray Ionization* / methods

Substances

Nitrogen