Progress of Dicyanomethylene-4H-Pyran Derivatives in Biological Sensing Based on ICT Effect

Ting-Ting Hou; Yi Cai; Zhen-Yu Zhang; Cai-Yun Wang; Ying-Hao Tang; Ming-Qiang Zhu; Ya-Long Wang

doi:10.3389/fchem.2022.903253

Progress of Dicyanomethylene-4H-Pyran Derivatives in Biological Sensing Based on ICT Effect

Front Chem. 2022 May 23:10:903253. doi: 10.3389/fchem.2022.903253. eCollection 2022.

Authors

Ting-Ting Hou¹, Yi Cai¹, Zhen-Yu Zhang¹, Cai-Yun Wang¹, Ying-Hao Tang¹, Ming-Qiang Zhu², Ya-Long Wang^{1

2

3}

Affiliations

¹ Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering, Hainan University, Haikou, China.
² Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China.
³ One Health Institute, Hainan University, Haikou, China.

Abstract

As one of the typical fluorescent cores, dicyanomethylene-4H-pyran (DCM) derivatives exhibit excellent photophysical and photochemical properties, such as large Stokes shift, excellent light stability, and tunable near-infrared (NIR) emission. The luminescence mechanism of DCM probes mainly depends on the intramolecular charge transfer (ICT). Hence, by regulating the ICT process, the probes can specifically act on the target molecule. Accordingly, a series of NIR DCM probes have been constructed to detect the ions, reactive oxygen species (ROS), and biological macromolecules in cells. However, there is no relevant review to summarize it at present. This minireview mainly summarizes the NIR DCM probes based on ICT effect and their applications in biosensors and biological imaging in recent years. This will be beneficial to innovatively construct new DCM probes and actively promote their application in the future.

Keywords: bioimaging; biosensor; dicyanomethylene-4H-pyran (DCM); intramolecular charge transfer; near-infrared probe.

Publication types

Review