Emerging roles for lncRNA-NEAT1 in colorectal cancer

Shirin Azizidoost; Farhoodeh Ghaedrahmati; Omid Anbiyaee; Riyadh Ahmad Ali; Maryam Cheraghzadeh; Maryam Farzaneh

doi:10.1186/s12935-022-02627-6

Emerging roles for lncRNA-NEAT1 in colorectal cancer

Cancer Cell Int. 2022 Jun 8;22(1):209. doi: 10.1186/s12935-022-02627-6.

Authors

Shirin Azizidoost¹, Farhoodeh Ghaedrahmati², Omid Anbiyaee³, Riyadh Ahmad Ali⁴, Maryam Cheraghzadeh⁵, Maryam Farzaneh⁶

Affiliations

¹ Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Cardiovascular Research Center, Nemazi Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
⁴ Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Kurdistan Region, Iraq.
⁵ Department of Biochemistry, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁶ Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. farzaneh-m@ajums.ac.ir.

Abstract

Colorectal cancer (CRC) is the third cause of cancer death in the world that arises from the glandular and epithelial cells of the large intestine, during a series of genetic or epigenetic alternations. Recently, long non-coding RNAs (lncRNAs) has opened a separate window of research in molecular and translational medicine. Emerging evidence has supported that lncRNAs can regulate cell cycle of CRC cells. LncRNA NEAT1 has been verified to participate in colon cancer development and progression. NEAT1 as a competing endogenous RNA could suppress the expression of miRNAs, and then regulate molecules downstream of these miRNAs. In this review, we summarized emerging roles of NEAT1 in CRC cells.

Keywords: Colorectal cancer; NEAT1; Progression; lncRNAs.

Publication types

Review