No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis

Diana H Quan; Alexander J Kwong; Philip M Hansbro; Warwick J Britton

doi:10.1183/16000617.0252-2021

No smoke without fire: the impact of cigarette smoking on the immune control of tuberculosis

Eur Respir Rev. 2022 Jun 7;31(164):210252. doi: 10.1183/16000617.0252-2021. Print 2022 Jun 30.

Authors

Diana H Quan^{1

2}, Alexander J Kwong³, Philip M Hansbro⁴, Warwick J Britton^{5

6

2}

Affiliations

¹ Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Sydney, Australia d.quan@centenary.org.au.
² D.H. Quan and W.J. Britton contributed equally to this article as lead authors and supervised the work.
³ NSW Dept of Education and Training, Parramatta, Australia.
⁴ Centre for Inflammation, Centenary Institute and University of Technology Sydney, Sydney, Australia.
⁵ Tuberculosis Research Program at the Centenary Institute, The University of Sydney, Sydney, Australia.
⁶ Dept of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, Australia.

Abstract

Cigarette smoke (CS) exposure is a key risk factor for both active and latent tuberculosis (TB). It is associated with delayed diagnosis, more severe disease progression, unfavourable treatment outcomes and relapse after treatment. Critically, CS exposure is common in heavily populated areas with a high burden of TB, such as China, India and the Russian Federation. It is therefore prudent to evaluate interventions for TB while taking into account the immunological impacts of CS exposure. This review is a mechanistic examination of how CS exposure impairs innate barrier defences, as well as alveolar macrophage, neutrophil, dendritic cell and T-cell functions, in the context of TB infection and disease.

Publication types

Review

MeSH terms

Cigarette Smoking* / adverse effects
Cigarette Smoking* / epidemiology
Humans
Latent Tuberculosis*
Neutrophils
Nicotiana
Tuberculosis*