Primary intraosseous squamous cell carcinoma is a highly malignant but rare tumor within jaws. We reported the 18F-FDG PET/CT findings of primary intraosseous squamous cell carcinoma of the mandible in a 42-year-old man. 18F-FDG PET/CT identified a cystic lesion in the mandible with irregular annular uptake of 18F-FDG, which has been confirmed as primary intraosseous squamous cell carcinoma pathologically.
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