Finding your niche: immune evasion in quiescent tumor reservoirs

Trever T Greene; Katelynn R Kazane; Elina I Zuniga

doi:10.1016/j.it.2022.05.003

Finding your niche: immune evasion in quiescent tumor reservoirs

Trends Immunol. 2022 Jul;43(7):500-502. doi: 10.1016/j.it.2022.05.003. Epub 2022 Jun 5.

Authors

Trever T Greene¹, Katelynn R Kazane¹, Elina I Zuniga²

Affiliations

¹ Division of Biological Sciences, University of California, San Diego, CA 92093, USA.
² Division of Biological Sciences, University of California, San Diego, CA 92093, USA. Electronic address: eizuniga@ucsd.edu.

Abstract

Emerging immunotherapies offer a new hope for cancer patients but are not always effective even when a tumor is recognized by the immune system. Baldominos and colleagues address this challenge by characterizing a resilient niche of metabolically unique quiescent cancer cells (QCCs) that resist T cell-mediated control.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Immune Evasion*
Immunotherapy
Neoplasms*
T-Lymphocytes
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding