Association Between ABCA1 Gene Polymorphisms and the Risk of Hypertension in the Chinese Han Population

Front Public Health. 2022 May 20:10:878610. doi: 10.3389/fpubh.2022.878610. eCollection 2022.

Abstract

Background: Hypertension is rising as a major public health burden around the world. This study explored the association between single-nucleotide polymorphisms (SNPs) in the adenosine triphosphate (ATP)-Binding Cassette Subfamily A1 (ABCA1) gene and hypertension among Chinese Han adults.

Method: A total of 2,296 Han Chinese in southeast China were recruited for this study. We collected medical reports, lifestyle details, and blood samples from individuals. The polymerase chain reaction-ligase detection reaction (PCR-LDR) method was used to detect the genotypes of these SNPs in the ABCA1 gene.

Results: After adjusting some covariates, the additive and recessive models of the rs2472510 and rs2515614 were significantly associated with hypertension. The haplotypes TCTA (rs2297406-rs2472433-rs2472510-rs2515614) were associated with high SBP, and the haplotypes CCTA, TCTA, and TTTA were associated with high diastolic blood pressure (DBP).

Conclusion: The results of the relationship between the polymorphisms of rs2297406, rs2472433, rs2472510, and rs2515614 in ABCA1 and hypertension in southeastern China would provide a theoretical basis for genetic screening and disease prevention.

Keywords: ABCA1; Chinese; association; gene polymorphisms; hypertension.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter 1 / genetics
  • Adult
  • Asian People* / genetics
  • China / epidemiology
  • Genotype
  • Humans
  • Hypertension* / epidemiology
  • Hypertension* / genetics
  • Polymorphism, Single Nucleotide

Substances

  • ABCA1 protein, human
  • ATP Binding Cassette Transporter 1