Role and mechanism of BMP4 in bone, craniofacial, and tooth development

Yuer Ye; Zhiwei Jiang; Yiqi Pan; Guoli Yang; Ying Wang

doi:10.1016/j.archoralbio.2022.105465

Role and mechanism of BMP4 in bone, craniofacial, and tooth development

Arch Oral Biol. 2022 Aug:140:105465. doi: 10.1016/j.archoralbio.2022.105465. Epub 2022 May 20.

Authors

Yuer Ye¹, Zhiwei Jiang¹, Yiqi Pan¹, Guoli Yang¹, Ying Wang¹

Affiliation

¹ The Affiliated of Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Disease, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou 310006, China.

PMID: 35662681
DOI: 10.1016/j.archoralbio.2022.105465

Abstract

Objective: This review aimed to present an overview of the effect of bone morphogenetic protein 4 (BMP4) on craniofacial and skeletal development, particularly the specific role of BMP4 in tooth development.

Design: The search for this narrative review was conducted in PubMed, Web of Science, Embase, and ScienceDirect using relevant keywords, including checking reference lists of journal articles by hand searching.

Results: Mutations or deletions of BMP4 cause tissue development defects in mice and humans, such as fragile bone, craniofacial deformity, cleft lip and palate, tooth development stagnation, and abnormal structure.

Conclusions: BMP4 is a reliable and vital candidate to regulate the development of bones, craniofacies, and teeth. It also has high clinical application potential.

Keywords: Bone morphogenetic protein 4; Craniofacial anomalies; Dentin; Odontoblast; Osteoblast.

Publication types

Review

MeSH terms

Animals
Bone Morphogenetic Protein 4 / genetics
Bone Morphogenetic Protein 4 / metabolism
Cleft Lip* / genetics
Cleft Palate* / genetics
Mice
Odontogenesis / genetics
Tooth*

Substances

Bmp4 protein, mouse
Bone Morphogenetic Protein 4