Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Kwesi Z Tandoh; Collins M Morang'a; Michael Wilson; Neils B Quashie; Nancy O Duah-Quashie

doi:10.1016/j.pt.2022.05.004

Malaria artemisinin resistance: an extracellular vesicles export hypothesis

Trends Parasitol. 2022 Aug;38(8):614-617. doi: 10.1016/j.pt.2022.05.004. Epub 2022 Jun 2.

Authors

Kwesi Z Tandoh¹, Collins M Morang'a², Michael Wilson³, Neils B Quashie⁴, Nancy O Duah-Quashie⁵

Affiliations

¹ West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana. Electronic address: kztandoh@st.ug.edu.gh.
² West African Centre for Cell Biology of Infectious Pathogens, Department of Biochemistry, Cell and Molecular Biology, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
³ Department of Parasitology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.
⁴ Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana; Centre for Tropical Clinical Pharmacology and Therapeutics, School of Medicine and Dentistry, College of Health Sciences, University of Ghana, Accra, Ghana.
⁵ Department of Epidemiology, Noguchi Memorial Institute for Medical Research, College of Health Sciences, University of Ghana, Accra, Ghana.

PMID: 35661626
DOI: 10.1016/j.pt.2022.05.004

Abstract

Plasmodium falciparum causes malaria, and its resistance to artemisinin (ART) - a drug used for managing malaria - threatens to interfere with the effective control of malaria. ART resistance (ARTr) is driven by increased tolerance to oxidative stress and reduced haemoglobin trafficking to the food vacuole. We discuss how extracellular vesicles (EVs) may play a role in developing ARTr.

Keywords: artemisinin resistance; extracellular vesicles; hypothetical model.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials* / pharmacology
Antimalarials* / therapeutic use
Artemisinins* / pharmacology
Artemisinins* / therapeutic use
Drug Resistance
Extracellular Vesicles*
Humans
Malaria* / drug therapy
Malaria, Falciparum* / drug therapy
Plasmodium falciparum

Substances

Antimalarials
Artemisinins