Are phenome-wide association studies feasible in a developing country?

Gerard G Dumancas; Destiny Harrison; Jonathan Adam Rico; Pia Regina Fatima C Zamora; Aretha G Liwag; Joselito F Villaruz; Ma Luz Vicenta V Guanzon; Hans Francis D Ferraris; Patrick Joseph B Jalandoni; Webster F Padernal; Bea Nestie L Villareal; Ria A Maculada; Rachael Mae A Fernandez; Felix Ray Villa; Romulo de Castro

doi:10.1016/j.tig.2022.05.003

Are phenome-wide association studies feasible in a developing country?

Trends Genet. 2022 Sep;38(9):885-888. doi: 10.1016/j.tig.2022.05.003. Epub 2022 May 31.

Authors

Gerard G Dumancas¹, Destiny Harrison², Jonathan Adam Rico³, Pia Regina Fatima C Zamora³, Aretha G Liwag⁴, Joselito F Villaruz⁴, Ma Luz Vicenta V Guanzon⁵, Hans Francis D Ferraris⁵, Patrick Joseph B Jalandoni⁶, Webster F Padernal⁶, Bea Nestie L Villareal⁶, Ria A Maculada⁶, Rachael Mae A Fernandez⁶, Felix Ray Villa⁶, Romulo de Castro⁷

Affiliations

¹ Department of Chemistry, Loyola Science Center, The University of Scranton, Scranton, PA 18510, USA; Balik Scientist Program, Department of Science and Technology-Philippine Council for Health Research and Development, Bicutan, Taguig City, 1631, Philippines. Electronic address: gerard.dumancas@scranton.edu.
² Department of Mathematics and Physical Sciences, Louisiana State University - Alexandria, Alexandria, LA 71302, USA.
³ Center for Informatics, University of San Agustin, Gen. Luna St, Iloilo City, 5000, Philippines.
⁴ West Visayas State University, Luna St, Lapaz, Iloilo City, 5000, Philippines.
⁵ Corazon Locsin Montelibano Memorial Regional Hospital, Lacson St, Bacolod, Negros Occidental, 6100, Philippines.
⁶ The Medical City Iloilo, Iloilo City, 5000, Philippines.
⁷ Center for Informatics, University of San Agustin, Gen. Luna St, Iloilo City, 5000, Philippines; Balik Scientist Program, Department of Science and Technology-Philippine Council for Health Research and Development, Bicutan, Taguig City, 1631, Philippines.

PMID: 35660028
DOI: 10.1016/j.tig.2022.05.003

Abstract

Phenome-wide association studies (PheWASs), a powerful approach that examines phenotypes associated with a genetic marker, have been used extensively in highly developed countries. Although there may be a clear need for PheWAS in a developing country such as the Philippines, limitations related to resources and practicality would make conducting them a challenge.

Keywords: PheWAS; Philippines; feasibility; genotype; phenome-wide association study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Developing Countries
Genome-Wide Association Study*
Phenotype
Polymorphism, Single Nucleotide*