Shooting for the moon: Genome editing for pig heart xenotransplantation

David K C Cooper; S Sikandar Raza; Ryan Chaban; Richard N Pierson 3rd

doi:10.1016/j.jtcvs.2022.04.032

Shooting for the moon: Genome editing for pig heart xenotransplantation

J Thorac Cardiovasc Surg. 2023 Sep;166(3):973-980. doi: 10.1016/j.jtcvs.2022.04.032. Epub 2022 May 7.

Authors

David K C Cooper¹, S Sikandar Raza², Ryan Chaban³, Richard N Pierson 3rd¹

Affiliations

¹ Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
² University of Alabama at Birmingham, Birmingham, Ala.
³ Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, Mass; Department of Cardiovascular Surgery, University Hospital of Johannes Gutenberg University, Mainz, Germany. Electronic address: rchaban@mgh.harvard.edu.

PMID: 35659123
PMCID: PMC10124774 (available on 2024-09-01)
DOI: 10.1016/j.jtcvs.2022.04.032

Abstract

Gene-edited pigs could eventually provide organs that are safely and effectively protected from the human immune response without exogenous immunosuppression.

Keywords: gene editing; heart; kidney; pig; xenotransplantation.

Publication types

Editorial
Research Support, N.I.H., Extramural

MeSH terms

Animals
Animals, Genetically Modified
Gene Editing*
Graft Rejection*
Heart
Swine
Thorax
Transplantation, Heterologous

Abstract

Publication types

MeSH terms

Grants and funding