High-dose stereotactic radiotherapy boost in the treatment of squamous cell carcinoma of the head and neck region

Radiat Oncol. 2022 Jun 3;17(1):103. doi: 10.1186/s13014-022-02069-4.

Abstract

Background: Surgical resection with adjuvant concurrent radiochemotherapy is the standard of care for stage III-IV oral cavity cancer. In some cases, the dynamic course of the disease is out of the prepared schedule of treatment. In that event, a stereotactic radiosurgery boost might be the only chance for disease control.

Case presentation: Here, we present a case study of a patient with oral cancer who underwent surgery. During adjuvant radiotherapy, a metastatic cervical lymph node was diagnosed based on fine-needle aspiration biopsy. To increase the total dose to the metastatic tumor, a stereotactic radiosurgery boost of 1 × 18 Gy was performed two days after the last fraction of conventional radiotherapy. The early and late tolerance of this treatment were positive. During the 18-month follow-up, locoregional recurrence was not detected. The patient died due to secondary malignancy.

Conclusions: This paper shows that a stereotactic radiosurgery boost added to adjuvant conventional radiotherapy is an effective approach permitting the maintenance of good local control in well-selected patients.

Keywords: Head and neck cancer; Radiosurgery boost; Squamous cell carcinoma; Stereotactic radiotherapy.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Squamous Cell* / pathology
  • Carcinoma, Squamous Cell* / radiotherapy
  • Carcinoma, Squamous Cell* / surgery
  • Head and Neck Neoplasms* / radiotherapy
  • Head and Neck Neoplasms* / surgery
  • Humans
  • Mouth Neoplasms* / radiotherapy
  • Neoplasm Recurrence, Local
  • Radiosurgery*
  • Squamous Cell Carcinoma of Head and Neck