Proteoforms and Proteoform Families: Past, Present, and Future

Methods Mol Biol. 2022:2500:1-4. doi: 10.1007/978-1-0716-2325-1_1.

Abstract

The Human Proteoform Project is an ambitious international effort to accelerate the development of technologies for proteoform analysis and to establish comprehensive atlases of proteoforms for humans and model organisms. Proteoforms are the ultimate molecular effectors of function in biology and are thus central to understanding that function. Proteoform analysis as it is practiced today is almost exclusively accomplished by mass spectrometry (MS) and is rapidly advancing in its capabilities. This volume presents a beautiful snapshot of emerging technologies at the exciting frontier of MS-based proteoform analysis.

Keywords: Human Proteoform Project; Mass spectrometry; Proteoform; Proteoform Family.

MeSH terms

  • Humans
  • Mass Spectrometry / methods
  • Protein Processing, Post-Translational*
  • Proteomics* / methods