Shielding Surfaces from Viruses and Bacteria with a Multiscale Coating

Deepu Ashok; Mahdiar Taheri; Puneet Garg; Daryl Webb; Pawan Parajuli; Yi Wang; Bronte Funnell; Bradley Taylor; David C Tscharke; Takuya Tsuzuki; Naresh K Verma; Antonio Tricoli; David R Nisbet

doi:10.1002/advs.202201415

Shielding Surfaces from Viruses and Bacteria with a Multiscale Coating

Adv Sci (Weinh). 2022 Aug;9(23):e2201415. doi: 10.1002/advs.202201415. Epub 2022 Jun 3.

Authors

Deepu Ashok^{1

2}, Mahdiar Taheri³, Puneet Garg^{1

2}, Daryl Webb⁴, Pawan Parajuli⁵, Yi Wang¹, Bronte Funnell¹, Bradley Taylor¹, David C Tscharke⁶, Takuya Tsuzuki³, Naresh K Verma⁵, Antonio Tricoli^{2

7}, David R Nisbet^{1

8}

Affiliations

¹ Laboratory of Advanced Biomaterials, Research School of Chemistry and the John Curtin School of Medical Research, The Australian National University, Canberra, 2601, Australia.
² Nanotechnology Research Laboratory, Research School of Chemistry, The Australian National University, Canberra, 2601, Australia.
³ Laboratory of Advanced Nanomaterials for Sustainability, Research School of Electrical, Energy and Materials Engineering, The Australian National University, Canberra, 2601, Australia.
⁴ Centre for Advanced Microscopy, Australian National University, Canberra, 2601, Australia.
⁵ Division of Biomedical Science and Biochemistry, Research School of Biology, The Australian National University, Canberra, 2601, Australia.
⁶ John Curtin School of Medical Research, Australian National University, 131 Garran Road, Acton, ACT, 2601, Australia.
⁷ Nanotechnology Research Laboratory, Faculty of Engineering, The University of Sydney, Sydney, 2006, Australia.
⁸ The Graeme Clark Institute, Faculty of Engineering and Information Technology and Faculty of Medicine, Dentistry and Health Services, The University of Melbourne, Melbourne, 3010, Australia.

Abstract

The spread of viral and bacterial pathogens mediated by contact with surfaces is a leading cause of infection worldwide. COVID-19 and the continuous rise of deaths associated with antibiotic-resistant bacteria highlight the need to impede surface-mediated transmission. A sprayable coating with an intrinsic ability to resist the uptake of bacteria and viruses from surfaces and droplets, such as those generated by sneezing or coughing, is reported. The coating also provides an effective microbicidal functionality against bacteria, providing a dual barrier against pathogen uptake and transmission. This antimicrobial functionality is fully preserved following scratching and other induced damage to its surface or 9 days of submersion in a highly concentrated suspension of bacteria. The coatings also register an 11-fold decrease in viral contamination compared to the noncoated surfaces.

Keywords: ZIF-8 metal-organic frameworks (MOFs); antibacterial; antiviral; infections; multiscale coatings.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Infective Agents* / pharmacology
Bacteria
COVID-19*
Humans
Viruses*

Substances

Anti-Bacterial Agents
Anti-Infective Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding