A global bibliometric and visualized analysis of bacteria-mediated cancer therapy

Jiawei Wang; Mohammed Maniruzzaman

doi:10.1016/j.drudis.2022.05.023

A global bibliometric and visualized analysis of bacteria-mediated cancer therapy

Drug Discov Today. 2022 Oct;27(10):103297. doi: 10.1016/j.drudis.2022.05.023. Epub 2022 May 30.

Authors

Jiawei Wang¹, Mohammed Maniruzzaman²

Affiliations

¹ Pharmaceutical Engineering and 3D Printing (PharmE3D) Lab, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA.
² Pharmaceutical Engineering and 3D Printing (PharmE3D) Lab, Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA. Electronic address: m.maniruzzaman@austin.utexas.edu.

Abstract

Bacteriotherapy has proved to be a powerful tool to fight against cancer. Herein, we used VOSviewer, CiteSpace, and Python to perform the first global bibliometric analysis of the literature from 2012 to 2021 on bacteria-mediated cancer therapy. Based on the results, East Asia and North America contributed the most publications to this research area. Additionally, the keyword analysis indicated that immunotherapy and nanoparticle (NP)-based drug delivery systems have long been popular topics in cancer bacteriotherapy, whereas the gut microbiota and probiotics are emerging research hotspots. This study provides crucial insights into the historical development of bacteria-mediated cancer therapy from 2012 to 2021, which will be helpful for scientists to conduct further investigation into this promising field.

Keywords: Bacteria; Bibliometric analysis; Cancer; Cancer bacteriotherapy; Immunotherapy.

Publication types

Research Support, U.S. Gov't, P.H.S.
Research Support, N.I.H., Extramural

MeSH terms

Bacteria
Bibliometrics
Biomedical Research*
Gastrointestinal Microbiome*
Humans
Neoplasms* / drug therapy

Grants and funding

R01 FD007456/FD/FDA HHS/United States