ROMPISA: Ring-Opening Metathesis Polymerization-Induced Self-Assembly

Daniel B Wright; Mollie A Touve; Lisa Adamiak; Nathan C Gianneschi

doi:10.1021/acsmacrolett.7b00408

ROMPISA: Ring-Opening Metathesis Polymerization-Induced Self-Assembly

ACS Macro Lett. 2017 Sep 19;6(9):925-929. doi: 10.1021/acsmacrolett.7b00408. Epub 2017 Aug 15.

Authors

Daniel B Wright^{1

2}, Mollie A Touve^{3

4}, Lisa Adamiak^{5

6}, Nathan C Gianneschi^{5

6}

Affiliations

¹ Department of Chemistry, ‡Department of Materials Science and Engineering, and §Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States of America.
² Department of Chemistry and Biochemistry, ⊥Department of NanoEngineering, and #Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States of America.
³ Department of Chemistry, Department of Materials Science and Engineering, and §Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States of America.
⁴ Department of Chemistry and Biochemistry, Department of NanoEngineering, and #Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States of America.
⁵ Department of Chemistry, Department of Materials Science and Engineering, and Department of Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States of America.
⁶ Department of Chemistry and Biochemistry, Department of NanoEngineering, and Materials Science and Engineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States of America.

PMID: 35650892
DOI: 10.1021/acsmacrolett.7b00408

Abstract

Herein we report a polymerization-induced self-assembly (PISA) process with ring-opening metathesis polymerization (ROMP). We utilize a peptide-based norbornenyl monomer as a hydrophobic unit to provide a range of nanostructures at room temperature yet at high solids concentrations of 20 wt % in combination with an oligoethylene glycol based norbornenyl monomer. Evaluation of the polymerizations under mild conditions highlight that good control is maintained along with high monomer conversion of greater than 99%, indicating that the living polymerization is unaffected during the PISA process. The demonstration broadens the scope of the PISA process to a new living polymerization methodology toward the development of easily accessible and highly functionalized nanostructures in situ.