Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression

Yasuhiro Nakagawa; Atsuhiro Saitou; Takao Aoyagi; Masanobu Naito; Mitsuhiro Ebara

doi:10.1021/acsmacrolett.7b00592

Apoptotic Cell Membrane-Inspired Polymer for Immunosuppression

ACS Macro Lett. 2017 Sep 19;6(9):1020-1024. doi: 10.1021/acsmacrolett.7b00592. Epub 2017 Sep 1.

Authors

Yasuhiro Nakagawa^{1

2}, Atsuhiro Saitou³, Takao Aoyagi⁴, Masanobu Naito^{2

5}, Mitsuhiro Ebara^{1

2

6}

Affiliations

¹ International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science (NIMS), 1-1, Namiki, Tsukuba, Ibaraki, Japan.
² Materials and Science Engineering, Graduate School of Pure and Applied Science, University of Tsukuba, Ibaraki, Japan.
³ Development of Medical Innovation, Osaka University Hospital, Osaka, Japan.
⁴ Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan.
⁵ Research Center for Strategic Materials, National Institute for Materials Science (NIMS), Ibaraki, Japan.
⁶ Department of Materials Science and Technology, Graduate School of Industrial Science and Technology, Tokyo University of Science, Tokyo, Japan.

PMID: 35650882
DOI: 10.1021/acsmacrolett.7b00592

Abstract

Apoptotic cell death serves important roles in homeostasis by eliminating dangerous, damaged, or unnecessary cells without causing an inflammatory response by externalizing phosphatidylserine to the outer leaflet in the phospholipid bilayer. In this study, we newly designed apoptotic cell membrane-inspired monomer and polymer which have the phosphoryl serine group as the anti-inflammatory functional moiety and demonstrate here for the first time that administration of an apoptotic cell membrane-inspired phosphorylserine polymer can protect murine macrophages (RAW 264.7) from lipopolysaccharide-induced inflammation. Interestingly, statistical copolymers with phosphorylcholine monomer that mimicked more precisely the apoptotic cell membrane result in more effective suppression of macrophage activation. This study provides new insights into the rational design of effective polymeric materials for anti-inflammatory therapies.