Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO-TiO2-Au Nanocomposite-Modified Electrode

Xin-Yang Lu; Jing Li; Fen-Ying Kong; Mei-Jie Wei; Pei Zhang; Ying Li; Hai-Lin Fang; Wei Wang

doi:10.3389/fchem.2022.892919

Improved Performance for the Electrochemical Sensing of Acyclovir by Using the rGO-TiO₂-Au Nanocomposite-Modified Electrode

Front Chem. 2022 May 11:10:892919. doi: 10.3389/fchem.2022.892919. eCollection 2022.

Authors

Xin-Yang Lu¹, Jing Li¹, Fen-Ying Kong¹, Mei-Jie Wei¹, Pei Zhang¹, Ying Li¹, Hai-Lin Fang¹, Wei Wang¹

Affiliation

¹ School of Chemistry and Chemical Engineering, Yancheng Institute of Technology, Yancheng, China.

Abstract

An electrochemical sensor for sensitive sensing of acyclovir (ACV) was designed by using the reduced graphene oxide-TiO₂-Au nanocomposite-modified glassy carbon electrode (rGO-TiO₂-Au/GCE). Transmission electron microscopy, X-ray diffractometer, and X-ray photoelectron spectroscopy were used to confirm morphology, structure, and composition properties of the rGO-TiO₂-Au nanocomposites. Cyclic voltammetry and linear sweep voltammetry were used to demonstrate the analytical performance of the rGO-TiO₂-Au/GCE for ACV. As a result, rGO-TiO₂-Au/GCE exerted the best response for the oxidation of ACV under the pH of 6.0 PB solution, accumulation time of 80 s at open-circuit, and modifier amount of 7 µl. The oxidation peak currents of ACV increased linearly with its concentration in the range of 1-100 µM, and the detection limit was calculated to be 0.3 µM (S/N = 3). The determination of ACV concentrations in tablet samples also demonstrated satisfactory results.

Keywords: acyclovir; chemically modified electrode; electrochemical sensor; metallic oxide; reduced graphene oxide.