Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations

Honghong Ren; Qianjin Wang; Chunwang Li; Zongchang Li; Jinguang Li; Lulin Dai; Min Dong; Jun Zhou; Jingqi He; Yanhui Liao; Ying He; Xiaogang Chen; Jinsong Tang

doi:10.3389/fnmol.2022.845970

Differences in Cortical Thickness in Schizophrenia Patients With and Without Auditory Verbal Hallucinations

Front Mol Neurosci. 2022 May 12:15:845970. doi: 10.3389/fnmol.2022.845970. eCollection 2022.

Authors

Honghong Ren^{1

2}, Qianjin Wang^{1

2}, Chunwang Li³, Zongchang Li^{1

2}, Jinguang Li^{1

2}, Lulin Dai^{1

2}, Min Dong⁴, Jun Zhou^{1

2}, Jingqi He^{1

2}, Yanhui Liao⁵, Ying He^{1

2}, Xiaogang Chen^{1

2}, Jinsong Tang⁵

Affiliations

¹ Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, China.
² Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China.
³ Department of Radiology, Hunan Children's Hospital, Changsha, China.
⁴ Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
⁵ Department of Psychiatry, School of Medicine, Sir Run-Run Shaw Hospital, Zhejiang University, Hangzhou, China.

Abstract

Auditory verbal hallucinations (AVHs) are one of the most common and severe symptoms of schizophrenia (SCZ), but the neuroanatomical mechanisms underlying AVHs remain unclear. This study aimed to investigate whether persistent AVHs (pAVH) are associated with cortical thinning of certain brain regions in patients with SCZ. With the use of the 3T magnetic resonance imaging (MRI) technology, we acquired and analyzed data from 79 SCZ patients with pAVH (pAVH group), 60 SCZ patients without AVHs (non-AVH group), and 83 healthy controls (HC group). The severity of pAVH was assessed by the P3 hallucination items in the Positive and Negative Syndrome Scale (PANSS) and the Auditory Hallucinations Rating Scale (AHRS). Cortical thickness analysis was used to compare the region of interest (ROI) cortical thickness between the groups. The relationship between the severity of pAVH and cortical thickness was also explored. Compared with the non-AVH and HC groups, the pAVH group exhibited significantly reduced cortical thickness in the bilateral lateral orbitofrontal region (p < 0.0007, after Bonferroni correction); no significant difference was found between the non-AVH group and the HC group. The cortical thickness of the left lateral orbitofrontal cortex (P3: r = -0.44, p < 0.001; AHRS: r = -0.45, p < 0.001) and the right lateral orbitofrontal cortex (P3: r = -0.36, p = 0.002; AHRS: r = -0.33, p = 0.004) were negatively correlated with the severity of pAVH (after Bonferroni correction, p < 0.0125). Therefore, abnormal thickness of the bilateral lateral orbitofrontal cortices might be associated with pAVHs in SCZ patients.

Keywords: auditory verbal hallucinations; cortical thickness; magnetic resonance imaging; orbitofrontal; schizophrenia.