Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients

Yue Xi; Wei Wang; Hua Wang; Xiaolin Wang; Jie Zhang; Jing Zhao; Guixiang Wang; Jingang Gui; Xin Ni

doi:10.1016/j.clim.2022.109046

Impaired HPV-specific T-cell response in juvenile-onset recurrent respiratory papillomatosis patients

Clin Immunol. 2022 Aug:241:109046. doi: 10.1016/j.clim.2022.109046. Epub 2022 May 27.

Authors

Yue Xi¹, Wei Wang², Hua Wang³, Xiaolin Wang², Jie Zhang³, Jing Zhao³, Guixiang Wang³, Jingang Gui⁴, Xin Ni⁵

Affiliations

¹ Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Department of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
² Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
³ Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China.
⁴ Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: guijingang@bch.com.cn.
⁵ Laboratory of Tumor Immunology, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: nixin@bch.com.cn.

PMID: 35644521
DOI: 10.1016/j.clim.2022.109046

Abstract

Immunologic dysfunction is one of the most important mechanisms underlying the initiation and development of JORRP. The study aimed to explore whether HPV-specific T-cell response was impaired in JORRP patients. We found JORRP patients had a Th2-biased cytokine profile correlated with disease severity in peripheral system. JORRP patients had an increased memory T cells and a reduced naive T cells in circulation. Upon HPV6/11 antigens stimulation, T cells from JORRP patients exhibited a greater activation profile. Of note, JORRP patients presented with a greater number of IL-10- and IL-4-secreting HPV6/11 antigen responding cells than that of IFN-γ and TNF-α secreting responders. Furthermore, in response to HPV6/11 antigen stimulation, JORRP patients showed a reduced level of cell proliferation, an increased level of apoptosis and higher percentage of the differentiated T cells expressing the replicative senescent cell marker CD57. Impaired HPV-specific T-cell responses could be partly responsible for JORRP development.

Keywords: Cytokine; HPV; Immune imbalance; JORRP; T-cell response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Papillomavirus Infections* / complications
Respiratory Tract Infections*
T-Lymphocytes

Supplementary concepts

Recurrent respiratory papillomatosis