Optical-based biosensor for detection of oncomarker CA 125, recent progress and current status

Alexei Valerievich Yumashev; Mohammad Rudiansyah; Supat Chupradit; Mustafa M Kadhim; Abduladheem Turki Jalil; Walid Kamal Abdelbasset; Wanich Suksatan; Rosario Mireya Romero Parra; Yasser Fakri Mustafa; Bekhzod Abdullaev; Ramtin Bidares

doi:10.1016/j.ab.2022.114750

Optical-based biosensor for detection of oncomarker CA 125, recent progress and current status

Anal Biochem. 2022 Oct 15:655:114750. doi: 10.1016/j.ab.2022.114750. Epub 2022 May 25.

Affiliations

¹ Department of Prosthetic Dentistry, Sechenov First Moscow State Medical University, Moscow, Russia.
² Division of Nephrology & Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Lambung Mangkurat / Ulin Hospital, Banjarmasin, Indonesia.
³ Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
⁴ Department of Medical Laboratory Techniques, Dijlah University College, Baghdad, 10021, Iraq; Techniques Department, Al-Farahidi University, Baghdad, Iraq.
⁵ Medical Laboratories Techniques Department, Al-Mustaqbal University College, Babylon, Hilla, 51001, Iraq.
⁶ Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
⁷ Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
⁸ Department of General Studies, Universidad Continental, Lima, Peru.
⁹ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
¹⁰ Scientific Department, Akfa University, Tashkent, 111221, Uzbekistan.
¹¹ Department of Anatomy, Histology Forensic Medicine, Sapienza University of Rome, Rome, Italy. Electronic address: Ramtin.bds@gmail.com.

PMID: 35643149
DOI: 10.1016/j.ab.2022.114750

Abstract

Ovarian cancer (OV) is the second most mortal gynecological malignancy. The oncomarker CA125 has been used as the main ovarian cancer marker for diagnosing and screening ovarian cancer in stages I and II. Therefore, sensitive and real-time detection of CA 125 is critical in ovarian cancer monitoring. Various tests are used to diagnose the CA 125. In recent years, modern methods such as biosensor technology have replaced the old tests for rapid, sensitive and specific detection of CA 125. Various types of biosensors are being developed, among which Surface Plasmon resonance (SPR) biosensors are one of the most important and remarkable types. Considering the importance of SPR biosensors in the diagnosis of enocomarker CA 125, the main focus of the present study is to consolidate the research work from the past two decade to the present. Also, the advantages and challenges in SPR biosensors development have been considered in the detection of CA 125 oncomarker.

Keywords: Biosensors; CA 125; Nanomaterial; Ovarian cancer (OV); SPR.

Publication types

Review

MeSH terms

Biosensing Techniques* / methods
Early Detection of Cancer
Female
Humans
Ovarian Neoplasms* / diagnosis
Surface Plasmon Resonance / methods