Impaired exercise outcomes with significant bronchodilator responsiveness in children with prematurity-associated obstructive lung disease

Abstract

Introduction: Preterm-born children have their normal in-utero lung development interrupted, thus are at risk of short- and long-term lung disease. Spirometry and exercise capacity impairments have been regularly reported in preterm-born children especially those who developed chronic lung disease of prematurity (CLD) in infancy. However, specific phenotypes may be differentially associated with exercise capacity. We investigated exercise capacity associated with prematurity-associated obstructive (POLD) or prematurity-associated preserved ratio of impaired spirometry (pPRISm) when compared to preterm- and term-controls with normal lung function.

Materials and methods: Preterm- and term-born children identified through home screening underwent in-depth lung function and cardiorespiratory exercise testing, including administration of postexercise bronchodilator, as part of the Respiratory Health Outcomes in Neonates (RHiNO) study.

Results: From 241 invited children, aged 7-12 years, 202 underwent exercise testing including 18 children with POLD (percent predicted (%)FEV₁ and FEV₁ /FVC < LLN); 12 pPRISm (%FEV₁ < LLN and FEV₁ /FVC ≥ LLN), 106 preterm-controls (PT_c , %FEV₁ ≥ LLN) and 66 term-controls (T_c , %FEV₁ > 90%). POLD children had reduced relative workload, peak O₂ uptake, CO₂ production, and minute ventilation compared to T_c , and used a greater proportion of their breathing reserve compared to both control groups. pPRISm and PT_c children also had lower O₂ uptake compared to T_c . POLD children had the greatest response to postexercise bronchodilator, improving their %FEV₁ by 19.4% (vs 6.3%, 6% 6.3% in pPRISm PT_c, T_c , respectively; p < .001).

Conclusion: Preterm-born children with obstructive airway disease had the greatest impairment in exercise capacity, and significantly greater response to postexercise bronchodilators. These classifications can be used to guide treatment in children with POLD.

Keywords: albuterol; bronchopulmonary dysplasia; exercise test; premature birth; respiratory function tests.