COVID-19 and Pregnancy

Sonja A Rasmussen; Denise J Jamieson

doi:10.1016/j.idc.2022.01.002

COVID-19 and Pregnancy

Infect Dis Clin North Am. 2022 Jun;36(2):423-433. doi: 10.1016/j.idc.2022.01.002. Epub 2022 Jan 31.

Authors

Sonja A Rasmussen¹, Denise J Jamieson²

Affiliations

¹ Department of Pediatrics, University of Florida College of Medicine, 1600 Archer Road, Box 100296, Gainesville, Florida, 32610; Department of Obstetrics and Gynecology, University of Florida College of Medicine, Gainesville, FL, USA; Department of Epidemiology, University of Florida College of Public Health and Health Professions and College of Medicine, Gainesville, FL, USA. Electronic address: sonja.rasmussen@peds.ufl.edu.
² Emory University School of Medicine, Department of Gynecology and Obstetrics, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 4208, Atlanta, GA 30322, USA.

Abstract

Pregnancy seems to be a risk factor for severe disease with COVID-19. Although SARS-CoV-2 intrauterine transmission seems to be rare, most studies show COVID-19 during pregnancy increases the risk for pregnancy complications, with higher risk among those with severe disease compared with those mildly affected. Studies suggest that COVID-19 vaccination during pregnancy is safe and effective. Antibodies to SARS-CoV-2 have been found in umbilical cord blood and breast milk following maternal vaccination, which might provide protection to the infant. However, vaccination rates during pregnancy remain low. Studies are needed to understand ways to address SARS-CoV-2 vaccine hesitancy among pregnant persons.

Keywords: COVID-19; Intrauterine transmission; Pregnancy; Pregnancy complications; SARS-CoV-2; SARS-CoV-2 vaccine; mRNA vaccine.

Publication types

Review

MeSH terms

COVID-19 Vaccines / adverse effects
COVID-19*
Female
Humans
Pregnancy
SARS-CoV-2
Vaccination
Viral Vaccines*

Substances

COVID-19 Vaccines
Viral Vaccines