The effect of platelet rich plasma combined with celecoxib on knee function and pain in patients with knee osteoarthritis

Mingjun Nie; Jianzhong Zhao; Guangcheng Zhang; Jiazhu Tang; Wei Zhu; Qing Zhang

doi:10.12669/pjms.38.4.5558

The effect of platelet rich plasma combined with celecoxib on knee function and pain in patients with knee osteoarthritis

Pak J Med Sci. 2022 Mar-Apr;38(4Part-II):796-800. doi: 10.12669/pjms.38.4.5558.

Authors

Mingjun Nie¹, Jianzhong Zhao², Guangcheng Zhang³, Jiazhu Tang⁴, Wei Zhu⁵, Qing Zhang⁶

Affiliations

¹ Mingjun Nie, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.
² Jianzhong Zhao, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.
³ Guangcheng Zhang, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.
⁴ Jiazhu Tang, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.
⁵ Wei Zhu, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.
⁶ Qing Zhang, Department of Orthopedics, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, Jiangsu Province, P.R. China.

Abstract

Objectives: To analyze the immediate effect of platelet rich plasma, combined with celecoxib, on knee function and pain in patients with knee osteoarthritis.

Methods: The clinical data of 86 patients with knee osteoarthritis, treated in our hospital from January 2019 to January 2021, were analyzed retrospectively. According to the treatment records, patients were divided into a control group (n = 43, celecoxib) and a treatment group (n = 43, platelet rich plasma + celecoxib). The knee function, pain and clinical effect in the two groups were compared and analyzed using the Hospital for Special Surgery (HSS) knee score and the visual analog scale (VAS).

Results: The treatment group had a higher HSS score, and a lower VAS score compared to the control group (P<0.05). The clinical efficacy in the treatment group was higher than that in the control group (95.35% and 72.09% respectively, P<0.05).

Conclusions: Platelet rich plasma combined with celecoxib can promote the recovery of knee function and reduce pain in patients with knee osteoarthritis. This treatment combination also has a high immediate clinical effectiveness but needs further evaluation to find out the long term effects.

Keywords: Celecoxib; Knee function; Knee osteoarthritis; Platelet rich plasma; Retrospective analysis.