The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice

Xuewei Ye; Xionge Pi; Wenxin Zheng; Yingxin Cen; Jiahui Ni; Langyu Xu; Kefei Wu; Wei Liu; Lanjuan Li

doi:10.3389/fnut.2022.899421

The Methanol Extract of Polygonatum odoratum Ameliorates Colitis by Improving Intestinal Short-Chain Fatty Acids and Gas Production to Regulate Microbiota Dysbiosis in Mice

Front Nutr. 2022 May 12:9:899421. doi: 10.3389/fnut.2022.899421. eCollection 2022.

Authors

Xuewei Ye^{1

2}, Xionge Pi³, Wenxin Zheng², Yingxin Cen², Jiahui Ni², Langyu Xu², Kefei Wu², Wei Liu³, Lanjuan Li¹

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.
² Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Department of Basic Medical Sciences, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, China.
³ Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.

Abstract

The potential impacts of methanol extract from Polygonatum odoratum on (YZM) colonic histopathology, gut gas production, short-chain fatty acids (SCFAs), and intestinal microbiota composition were evaluated with dextran sulfate sodium (DSS)-induced colitis mice in this study. These results indicated that YZM increased colon length and ameliorated colonic histopathology in DSS-induced colitis mice. Moreover, YZM administration reversed intestinal microbiota compositions leading to the inhibition of H₂S-related bacteria (e.g., Desulfovibrionaceae) and the lower level of H₂S and higher contents of SCFA-related bacteria (e.g., Muribaculaceae). Taken together, the effects of methanol extract from Polygonatum odoratum are studied to provide new enlightenment and clues for its application as a functional food and clinical drug. Our study first revealed the relationship between intestinal gas production and key bacteria in ulcerative colitis.

Keywords: DSS-induced colitis mice; Polygonatum odoratum; SCFAs; gas production; microbiota.