Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases

Tengfei Xiao; Mingzhong Sun; Jingjing Kang; Chuanxiang Zhao

doi:10.3389/fimmu.2022.870952

Transient Receptor Potential Vanilloid1 (TRPV1) Channel Opens Sesame of T Cell Responses and T Cell-Mediated Inflammatory Diseases

Front Immunol. 2022 May 11:13:870952. doi: 10.3389/fimmu.2022.870952. eCollection 2022.

Authors

Tengfei Xiao¹, Mingzhong Sun¹, Jingjing Kang², Chuanxiang Zhao³

Affiliations

¹ Department of Clinical Laboratory, The Sixth Affiliated Hospital of Nantong University, Yancheng Third People's Hospital, Yancheng, China.
² Department of Clinical Laboratory, Affiliated Hospital of Nanjing University Medical School, Yancheng First People's Hospital, Yancheng, China.
³ Institute of Medical Genetics and Reproductive Immunity, School of Medical Science and Laboratory Medicine, Jiangsu College of Nursing, Huai'an, China.

Abstract

Transient receptor potential vanilloid1 (TRPV1) was primarily expressed in sensory neurons, and could be activated by various physical and chemical factors, resulting in the flow of extracellular Ca²⁺ into cells. Accumulating data suggest that the TRPV1 is expressed in some immune cells and is a novel regulator of the immune system. In this review, we highlight the structure and biological features of TRPV1 channel. We also summarize recent findings on its role in modulating T cell activation and differentiation as well as its protective effect in T cell-mediated inflammatory diseases and potential mechanisms.

Keywords: Ca2+; T cell; T cell-mediated inflammatory diseases; TRPV1; fever.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Sensory Receptor Cells
Sesamum*
T-Lymphocytes
TRPV Cation Channels
Transient Receptor Potential Channels*

Substances

TRPV Cation Channels
Transient Receptor Potential Channels