Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors

Ming-Ju Hsieh; Chih-Yang Huang; Rudolf Kiefer; Shin-Da Lee; Nancy Maurya; Bharath Kumar Velmurugan

doi:10.3390/molecules27103235

Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors

Molecules. 2022 May 18;27(10):3235. doi: 10.3390/molecules27103235.

Authors

Ming-Ju Hsieh^{1

2

3}, Chih-Yang Huang^{4

5

6

7

8}, Rudolf Kiefer⁹, Shin-Da Lee^{10

11

12}, Nancy Maurya¹³, Bharath Kumar Velmurugan¹⁴

Affiliations

¹ Oral Cancer Research Center, Changhua Christian Hospital, Changhua 50006, Taiwan.
² Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
³ School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.
⁴ Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung 41354, Taiwan.
⁵ Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
⁶ Graduate Institute of Biomedical Sciences, China Medical University, Taichung 40402, Taiwan.
⁷ Center of General Education, Buddhist Tzu Chi Medical Foundation, Tzu Chi University of Science and Technology, Hualien 970302, Taiwan.
⁸ Department of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan.
⁹ Conducting Polymers in Composites and Applications Research Group, Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.
¹⁰ Department of Physical Therapy, Asia University, Taichung 41354, Taiwan.
¹¹ Department of Physical Therapy, Graduate Institute of Rehabilitation Science, China Medical University, Taichung 406040, Taiwan.
¹² School of Rehabilitation Medicine, Weifang Medical University, Weifang 261053, China.
¹³ Botany Department, Government Science College, Pandhurna, Chhindwara, M.P., Pandhurna 480334, India.
¹⁴ Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City 758307, Vietnam.

Abstract

Foods rich in antioxidants such as lycopene have a major role in maintaining cardiac health. Lycopene, 80% of which can be obtained by consuming a common vegetable such as tomato, can prevent the disturbances that contribute to cardiovascular disease (CVD). The present work begins with a brief introduction to CVD and lycopene and its various properties such as bioavailability, pharmacokinetics, etc. In this review, the potential cardio-protective effects of lycopene that reduce the progression of CVD and thrombotic complications are detailed. Further, the protective effects of lycopene including in vitro, in vivo and clinical trials conducted on lycopene for CVD protective effects are explained. Finally, the controversial aspect of lycopene as a protective agent against CVD and toxicity are also mentioned.

Keywords: cardiovascular disease; in vitro studies; in vivo studies; lycopene; pharmacokinetics.

Publication types

Review

MeSH terms

Antioxidants / pharmacology
Antioxidants / therapeutic use
Cardiovascular Diseases* / drug therapy
Cardiovascular Diseases* / prevention & control
Carotenoids / pharmacology
Carotenoids / therapeutic use
Heart Disease Risk Factors
Humans
Lycopene / therapeutic use
Risk Factors

Substances

Antioxidants
Carotenoids
Lycopene

Grants and funding

This systematic review is partially supported by Ministry of Science and Technology, Taiwan (MOST 110-2314-B-468-004), as well as China Medical University and Weifang Medical University.