Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities

Bing-Chao Yan; Wei-Guang Wang; Ling-Mei Kong; Jian-Wei Tang; Xue Du; Yan Li; Pema-Tenzin Puno

doi:10.3390/jof8050543

Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities

J Fungi (Basel). 2022 May 23;8(5):543. doi: 10.3390/jof8050543.

Authors

Bing-Chao Yan^{1

2

3}, Wei-Guang Wang^{1

2}, Ling-Mei Kong^{1

2}, Jian-Wei Tang^{1

2

3}, Xue Du^{1

2

3}, Yan Li^{1

2}, Pema-Tenzin Puno^{1

2

3}

Affiliations

¹ State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
² Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, China.
³ University of Chinese Academy of Sciences, Beijing 100049, China.

Abstract

Cytochalasans from the endophytic fungi featured structure diversity. Our previous study has disclosed that cytochalasans from the endophytic fungus Phomopsis sp. shj2 exhibited an antimigratory effect. Further chemical investigation on Phomopsis sp. shj2 has led to the discovery of seven new cytochalasans (1-7), together with four known ones. Their structures were elucidated through extensive spectroscopic data interpretation and single-crystal X-ray diffraction analysis. Compounds 1-3 and 8-11 exhibited antimigratory effects against MDA-MB-231 in vitro with IC₅₀ values in the range of 1.01-10.42 μM.

Keywords: Phomopsis; antimigratory activity; cytochalasan; endophytic fungus.

Abstract

Grants and funding