Aqueous Extract of Phyllanthus emblica L. Alleviates Functional Dyspepsia through Regulating Gastrointestinal Hormones and Gut Microbiome In Vivo

Xiaoqing Li; Yilin Lin; Yiqi Jiang; Binbin Wu; Yigang Yu

doi:10.3390/foods11101491

Aqueous Extract of Phyllanthus emblica L. Alleviates Functional Dyspepsia through Regulating Gastrointestinal Hormones and Gut Microbiome In Vivo

Foods. 2022 May 20;11(10):1491. doi: 10.3390/foods11101491.

Authors

Xiaoqing Li¹, Yilin Lin¹, Yiqi Jiang¹, Binbin Wu², Yigang Yu¹

Affiliations

¹ College of Food Science and Engineering, South China University of Technology, Guangzhou 510006, China.
² Lui Che Woo Institute of Innovative Medicine, Hong Kong Hub of Paediatric Excellence (HK HOPE), The Chinese University of Hong Kong (CUHK), Hong Kong SAR, China.

Abstract

Phyllanthus emblica L. fruits were extracted by a hot water assistant with ultrasonication to obtain aqueous Phyllanthus emblica L. extract (APE). The ameliorating functional dyspepsia (FD) effect of a low dose (150 mg/kg) and a high dose (300 mg/kg) of APE was exhibited by determining the gastrointestinal motility, gastrointestinal hormones, and gut microbiome shifts in reserpine induced FD male balb/c mice. APE increased the gastrointestinal motility including the gastric emptying (GE) rate and small intestinal transit (SIT) rate. The level of serum gastrointestinal hormones such as motilin (MTL) and gastrin (GAS) increased, and the vasoactive intestinal peptide (VIP) level decreased after the administration of APE. Furthermore, the gut microbiome analysis demonstrated that APE could regulate the microbiome structure and restore homeostasis by elevating useful bacterial abundance, while simultaneously decreasing harmful bacterial abundance. This study demonstrated the ameliorating FD effect of APE and its potential efficacy in curing functional gastrointestinal disorders and maintaining a healthy digestive tract.

Keywords: aqueous Phyllanthus emblica L. extract; functional dyspepsia; gastrointestinal hormones; gut microbiome.

Grants and funding

Guangdong Province Department of Education (No.2013gjhz0003), the Guangdong Province Engineering Research Center for Bioactive Natural Products (2016B090920093), the Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods (2018B030322010), and the Program for Guangdong Introducing Innovative and Entrepreneurial Teams (2019ZT08N291).