Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock

Shutao Zheng; Yan Liang; Lu Li; Yiyi Tan; Qing Liu; Tao Liu; Xiaomei Lu

doi:10.3390/cells11101665

Revisiting the Old Data of Heat Shock Protein 27 Expression in Squamous Cell Carcinoma: Enigmatic HSP27, More Than Heat Shock

Cells. 2022 May 17;11(10):1665. doi: 10.3390/cells11101665.

Authors

Shutao Zheng¹, Yan Liang², Lu Li³, Yiyi Tan¹, Qing Liu¹, Tao Liu³, Xiaomei Lu¹

Affiliations

¹ State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
² Department of Pathology, Basic Medicine College, Xinjiang Medical University, Urumqi 830017, China.
³ Department of Clinical Laboratory, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.

Abstract

Initially discovered to be induced by heat shock, heat shock protein 27 (HSP27, also called HSPB1), a member of the small HSP family, can help cells better withstand or avoid heat shock damage. After years of studies, HSP27 was gradually found to be extensively engaged in various physiological or pathophysiological activities. Herein, revisiting the previously published data concerning HSP27, we conducted a critical review of the literature regarding its role in squamous cell carcinoma (SCC) from the perspective of clinicopathological and prognostic significance, excluding studies conducted on adenocarcinoma, which is very different from SCC, to understand the enigmatic role of HSP27 in the tumorigenesis of SCC, including normal mucosa, dysplasia, intraepithelial neoplasm, carcinoma in situ and invasive SCC.

Keywords: clinicopathological; heat shock protein 27(HSP27); prognostic; squamous cell carcinoma (SCC).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinoma, Squamous Cell* / pathology
HSP27 Heat-Shock Proteins* / genetics
HSP27 Heat-Shock Proteins* / metabolism
Heat-Shock Response
Humans

Substances

HSP27 Heat-Shock Proteins

Grants and funding

This study was partly supported by the National Innovation Research Group Cultivation Program (grant no. xyd2021C001), the Key Research and Development Project of the Xinjiang Uygur Autonomous Region (grant no. 2020B03003-1) and the special funds for the development of local science and technology from the central government (ZYYD2022B06).