A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

Oluwakemi Ebenezer; Michael Shapi; Jack A Tuszynski

doi:10.3390/biomedicines10051124

A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

Biomedicines. 2022 May 12;10(5):1124. doi: 10.3390/biomedicines10051124.

Authors

Oluwakemi Ebenezer^{1

2}, Michael Shapi¹, Jack A Tuszynski^{2

3

4}

Affiliations

¹ Department of Chemistry, Faculty of Natural Science, Mangosuthu University of Technology, Durban 4026, South Africa.
² Department of Physics, University of Alberta, Edmonton, AB T6G 2E1, Canada.
³ Department of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB T6G 1Z2, Canada.
⁴ Department of Mechanical and Aerospace Engineering, (DIMEAS), Politecnico di Torino, 10129 Turin, Italy.

Abstract

Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an important class of compounds for drug development; thus, they have attracted much attention. In the meantime, pyrazole derivatives have been synthesized as target structures and have demonstrated numerous biological activities such as antituberculosis, antimicrobial, antifungal, and anti-inflammatory. This review summarizes the results of published research on pyrazole derivatives synthesis and biological activities. The published research works on pyrazole derivatives synthesis and biological activities between January 2018 and December 2021 were retrieved from the Scopus database and reviewed accordingly.

Keywords: biological activities; derivatives; heterocycle; pyrazole; recent development; synthesis.

Publication types

Review

Grants and funding

This research received no external funding.