Mitochondria transfer and transplantation in human health and diseases

Zi-Hao Wang; Lu Chen; Wei Li; Lingchao Chen; Yi-Ping Wang

doi:10.1016/j.mito.2022.05.002

Mitochondria transfer and transplantation in human health and diseases

Mitochondrion. 2022 Jul:65:80-87. doi: 10.1016/j.mito.2022.05.002. Epub 2022 May 24.

Authors

Zi-Hao Wang¹, Lu Chen², Wei Li³, Lingchao Chen⁴, Yi-Ping Wang⁵

Affiliations

¹ Fudan University Shanghai Cancer Center, Key Laboratory of Breast Cancer in Shanghai, Shanghai Key Laboratory of Radiation Oncology, Cancer Institute, and The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 20032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 20032, China; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai 20032, China.
² State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
³ School of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 201318, China. Electronic address: liw_2014@sumhs.edu.cn.
⁴ Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, National Center for Neurological Disorders, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Neurosurgical Institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China. Electronic address: Chenlingchao12@sina.com.
⁵ Fudan University Shanghai Cancer Center, Key Laboratory of Breast Cancer in Shanghai, Shanghai Key Laboratory of Radiation Oncology, Cancer Institute, and The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 20032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 20032, China; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai 20032, China. Electronic address: yiping_wang@fudan.edu.cn.

PMID: 35623561
DOI: 10.1016/j.mito.2022.05.002

Abstract

Mitochondria are dynamic organelles responsible for energy production and cell metabolism. Disorders in mitochondrial function impair tissue integrity and have been implicated in multiple human diseases. Rather than constrained in host cells, mitochondria were recently found to actively travel between cells through nanotubes or extracellular vesicles. Mitochondria transportation represents a key mechanism of intercellular communication implicated in metabolic homeostasis, immune response, and stress signaling. Here we reviewed recent progress in mitochondria transfer under physiological and pathological conditions. Specifically, tumor cells imported mitochondria from adjacent cells in the microenvironment which potentially modulated cancer progression. Intercellular mitochondria trafficking also inspired therapeutic intervention of human diseases with mitochondria transplantation. Artificial mitochondria, generated through mitochondria genome engineering or mitochondria-nucleus hybridization, further advanced our understanding of mitochondrial biology and its therapeutic potential. Innovative tools and animal models of mitochondria transplantation will assist the development of new therapies for mitochondrial dysfunction-related diseases.

Keywords: Artificial mitochondria; Intercellular nanotube; Microvesicle; Mitochondria genome editing; Mitochondria transfer; Mitochondria transplantation; Synthetic biology.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Communication
Genome, Mitochondrial*
Homeostasis
Humans
Mitochondria / metabolism
Mitochondrial Diseases* / pathology