Flip-flop genomics: Charting inversions in the human population

Sophie Lanciano; Gael Cristofari

doi:10.1016/j.cell.2022.05.002

Flip-flop genomics: Charting inversions in the human population

Cell. 2022 May 26;185(11):1811-1813. doi: 10.1016/j.cell.2022.05.002.

Authors

Sophie Lanciano¹, Gael Cristofari²

Affiliations

¹ University Cote d'Azur, Inserm, CNRS, Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France.
² University Cote d'Azur, Inserm, CNRS, Institute for Research on Cancer and Aging of Nice (IRCAN), Nice, France. Electronic address: gael.cristofari@univ-cotedazur.fr.

PMID: 35623326
DOI: 10.1016/j.cell.2022.05.002

Abstract

Detecting large genomic inversions has long been challenging. In a new study, Porubsky et al. resolve these complex rearrangements in 41 individuals and discover wide regions that undergo recurrent inversions, some of which even toggle back and forth (Porubsky et al., 2022). Many of these regions are associated with genomic disorders.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Rearrangement*
Genomics*
Humans