Angiotensin receptors - affinitiy and beyond

Colin Sumners; Igor Maciel Souza Silva; U Muscha Steckelings

doi:10.1042/CS20220024

Angiotensin receptors - affinitiy and beyond

Clin Sci (Lond). 2022 May 27;136(10):799-802. doi: 10.1042/CS20220024.

Authors

Colin Sumners¹, Igor Maciel Souza Silva², U Muscha Steckelings²

Affiliations

¹ Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL, U.S.A.
² Department of Cardiovascular & Renal Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.

PMID: 35621123
DOI: 10.1042/CS20220024

Abstract

This commentary on the article "Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors" by Sanja Bosnyak et al. (Clini. Sci. (Lond.) (2011) 121(7): 297-303. https://doi.org/10.1042/CS20110036) summarises the main findings of the study, followed by a discussion of the findings and their relevance for various aspects of the biology of receptors of the renin-angiotensin system in the context of the current state of knowledge.

Keywords: pharmacodynamics; receptors; renin-angiotensin system.

MeSH terms

Angiotensin II* / metabolism
Peptides
Receptors, Angiotensin* / metabolism
Renin-Angiotensin System

Substances

Peptides
Receptors, Angiotensin
Angiotensin II