Hydrogel Nanoarchitectonics: An Evolving Paradigm for Ultrasensitive Biosensing

Zakia Sultana Nishat; Tanvir Hossain; Md Nazmul Islam; Hoang-Phuong Phan; Md A Wahab; Mohammad Ali Moni; Carlos Salomon; Mohammed A Amin; Abu Ali Ibn Sina; Md Shahriar A Hossain; Yusuf Valentino Kaneti; Yusuke Yamauchi; Mostafa Kamal Masud

doi:10.1002/smll.202107571

Hydrogel Nanoarchitectonics: An Evolving Paradigm for Ultrasensitive Biosensing

Small. 2022 Jul;18(26):e2107571. doi: 10.1002/smll.202107571. Epub 2022 May 27.

Authors

Zakia Sultana Nishat¹, Tanvir Hossain^{1

2}, Md Nazmul Islam³, Hoang-Phuong Phan⁴, Md A Wahab², Mohammad Ali Moni⁵, Carlos Salomon^{6

7}, Mohammed A Amin⁸, Abu Ali Ibn Sina⁹, Md Shahriar A Hossain^{2

10}, Yusuf Valentino Kaneti², Yusuke Yamauchi^{2

11

12}, Mostafa Kamal Masud^{1

2

12}

Affiliations

¹ Department of Biochemistry and Molecular Biology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, 3114, Bangladesh.
² Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland, Brisbane, QLD, 4072, Australia.
³ School of Health and Life Sciences, Teesside University, Tees Valley, Middlesbrough, TS1 3BA, UK.
⁴ Queensland Micro and Nanotechnology Centre, Griffith University, Nathan, QLD, 4111, Australia.
⁵ School of Health and Rehabilitation Sciences, Faculty of Health and Behavioural Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
⁶ Exosome Biology Laboratory, Centre for Clinical Diagnostics, University of Queensland Centre for Clinical Research, Royal Brisbane and Women's Hospital Faculty of Medicine, The University of Queensland, Herston, Brisbane City, QLD, 4029, Australia.
⁷ Departamento de Investigación, Postgrado y Educación Continua (DIPEC), Facultad de Ciencias de la Salud, Universidad del Alba, Santiago, 8320000, Chile.
⁸ Department of Chemistry, College of Science, Taif University, P. O. Box 11099, Taif, 21944, Saudi Arabia.
⁹ Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, MA, 02115, USA.
¹⁰ School of Mechanical and Mining Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD, 4072, Australia.
¹¹ School of Chemical Engineering, Faculty of Engineering, Architecture and Information Technology (EAIT), The University of Queensland, Brisbane, QLD, 4072, Australia.
¹² JST-ERATO Yamauchi Materials Space-Tectonics Project and International Center for Materials Nanoarchitectonics (WPI-MANA), National Institute for Materials Science, Tsukuba, Ibaraki, 305-0044, Japan.

PMID: 35620959
DOI: 10.1002/smll.202107571

Abstract

The integration of nanoarchitectonics and hydrogel into conventional biosensing platforms offers the opportunities to design physically and chemically controlled and optimized soft structures with superior biocompatibility, better immobilization of biomolecules, and specific and sensitive biosensor design. The physical and chemical properties of 3D hydrogel structures can be modified by integrating with nanostructures. Such modifications can enhance their responsiveness to mechanical, optical, thermal, magnetic, and electric stimuli, which in turn can enhance the practicality of biosensors in clinical settings. This review describes the synthesis and kinetics of gel networks and exploitation of nanostructure-integrated hydrogels in biosensing. With an emphasis on different integration strategies of hydrogel with nanostructures, this review highlights the importance of hydrogel nanostructures as one of the most favorable candidates for developing ultrasensitive biosensors. Moreover, hydrogel nanoarchitectonics are also portrayed as a promising candidate for fabricating next-generation robust biosensors.

Keywords: biosensors; hydrogel; nanoarchitectonic; nanobiotechnology; nanodiagnostics.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biosensing Techniques*
Hydrogels / chemistry
Nanostructures* / chemistry

Substances

Hydrogels