Lysine acylation causes collateral damage in inborn errors of metabolism

Sci Transl Med. 2022 May 25;14(646):eabq4863. doi: 10.1126/scitranslmed.abq4863. Epub 2022 May 25.

Abstract

Posttranslational modifications contribute to the pathology of methylmalonic acidemia and may be targetable via an acylation-resistant sirtuin (Head et al., this issue).

Publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Acylation
  • Amino Acid Metabolism, Inborn Errors*
  • Humans
  • Lysine* / metabolism
  • Protein Processing, Post-Translational

Substances

  • Lysine