Observed High Adherence to Recombinant Human Growth Hormone Treatment Using a Multi-Component Approach to Improve Adherence in Individuals with Growth Disorders

Stud Health Technol Inform. 2022 May 25:294:817-818. doi: 10.3233/SHTI220595.

Abstract

We explored whether a multi-component approach - using a digital health device, the easypod™ auto-injector, the 'MySupport' patient support programme (PSP) and a Patient Activation Measure® (PAM®) - could improve adherence in patients receiving recombinant human growth hormone (r-hGH). A 13-item PAM was used to assess caregiver self-reported knowledge, resulting in two PAM scores for 88 patients at four UK hospitals after an average of 5.6 months. Most patients improved their PAM score by ≥1 level (43%) or maintained it (>-1 and <1; 21%). In parallel, 74% of patients maintained (-5 to +5%) or improved (≥5%) their adherence. Further studies are required to evaluate a multi-component approach to adherence in a larger population and for a longer duration.

Keywords: Auto-injector; growth hormone; patient activation measure; patient support programme.

MeSH terms

  • Caregivers
  • Growth Disorders / epidemiology
  • Human Growth Hormone* / therapeutic use
  • Humans
  • Medication Adherence
  • Recombinant Proteins / therapeutic use
  • Self Report

Substances

  • Recombinant Proteins
  • Human Growth Hormone