Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension

Luca Marsili; Kevin R Duque; Andrea Sturchio; Gabriele Sobrero; Isabella Premoli; Alok K Dwivedi; Alberto J Espay; Aristide Merola

doi:10.1016/j.parkreldis.2022.05.002

Droxidopa reduces postural sway in Parkinson disease patients with orthostatic hypotension

Parkinsonism Relat Disord. 2022 Jun:99:62-64. doi: 10.1016/j.parkreldis.2022.05.002. Epub 2022 May 13.

Authors

Luca Marsili¹, Kevin R Duque², Andrea Sturchio³, Gabriele Sobrero⁴, Isabella Premoli⁵, Alok K Dwivedi⁶, Alberto J Espay⁷, Aristide Merola⁸

Affiliations

¹ James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: luca.marsili@uc.edu.
² James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: duqueykr@ucmail.uc.edu.
³ James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA; Department of Clinical Neuroscience, Neuro Svenningsson, Karolinska Institute, 171 76, Stockholm, Sweden. Electronic address: andrea.sturchio@gmail.com.
⁴ Autonomic and Orthostatic Hypotension Unit, Department of Medical Sciences; AOU Città della Salute e della Scienza di Torino, Turin, Italy. Electronic address: gabri.sobrero@gmail.com.
⁵ Biomarker Department, Division of Experimental Medicine, H. Lundbeck A/S, 2500, Copenhagen, Denmark; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, SE5 9RX, UK. Electronic address: ISPR@lundbeck.com.
⁶ Division of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Texas Tech University Health Sciences Center El Paso, Texas, USA. Electronic address: alok.dwivedi@ttuhsc.edu.
⁷ James J. and Joan A. Gardner Family Center for Parkinson's Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA. Electronic address: alberto.espay@uc.edu.
⁸ Department of Neurology, Wexner Medical Center, Ohio State University, Columbus, OH, USA. Electronic address: aristidemerola@hotmail.com.

PMID: 35605513
DOI: 10.1016/j.parkreldis.2022.05.002

Abstract

We evaluate the effect of droxidopa on gait and balance measures in nine patients with Parkinson's disease and neurogenic orthostatic hypotension. Computerized gait/balance analysis showed a significant effect of droxidopa in reducing postural sway. Future studies may determine if such effect translates into improvement in postural reflexes and falls.

Keywords: Droxidopa; Orthostatic hypotension; Parkinson disease; Postural sway; Wearables.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antiparkinson Agents / therapeutic use
Droxidopa* / therapeutic use
Humans
Hypotension, Orthostatic* / drug therapy
Hypotension, Orthostatic* / etiology
Parkinson Disease* / complications
Parkinson Disease* / drug therapy
Reflex

Substances

Antiparkinson Agents
Droxidopa