Prior statin and short-term outcomes of primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry

Abstract

Introduction: The relationship between statins and intracerebral hemorrhage outcomes is unclear.

Aim: We aimed to compare the in-hospital mortality and evacuation of intracranial hematoma rates in patients with primary intracerebral hemorrhage between prior statin users and nonusers.

Results: The final study population included 66,263 patients. Multivariable logistics analyses showed that prior statin use was not associated with in-hospital mortality for primary intracerebral hemorrhage (adjusted odd ratio 0.78, 95% CI 0.61-1.01), but reduced the proportion of patients undergoing evacuation of intracranial hematoma (adjusted odd ratio 0.70, 95% CI 0.61-0.82). Propensity score matching analyses yielded similar results.

Conclusion: Prior statin use was not associated with in-hospital mortality but did reduce evacuation of intracranial hematoma rates.

Keywords: cerebral hemorrhage; hydroxymethylglutaryl-CoA reductase inhibitors; mortality; treatment outcome.