Current methods for fabricating 3D cardiac engineered constructs

Nicholas Rogozinski; Apuleyo Yanez; Rahulkumar Bhoi; Moo-Yeal Lee; Huaxiao Yang

doi:10.1016/j.isci.2022.104330

Current methods for fabricating 3D cardiac engineered constructs

iScience. 2022 Apr 29;25(5):104330. doi: 10.1016/j.isci.2022.104330. eCollection 2022 May 20.

Authors

Nicholas Rogozinski¹, Apuleyo Yanez¹, Rahulkumar Bhoi¹, Moo-Yeal Lee¹, Huaxiao Yang¹

Affiliation

¹ Department of Biomedical Engineering, University of North Texas, 3940 N. Elm Street K240B, Denton, TX 76207-7102, USA.

Abstract

3D cardiac engineered constructs have yielded not only the next generation of cardiac regenerative medicine but also have allowed for more accurate modeling of both healthy and diseased cardiac tissues. This is critical as current cardiac treatments are rudimentary and often default to eventual heart transplants. This review serves to highlight the various cell types found in cardiac tissues and how they correspond with current advanced fabrication methods for creating cardiac engineered constructs capable of shedding light on various pathologies and providing the therapeutic potential for damaged myocardium. In addition, insight is given toward the future direction of the field with an emphasis on the creation of specialized and personalized constructs that model the region-specific microtopography and function of native cardiac tissues.

Keywords: 3d reconstruction of protein; Biomaterials; Materials science.

Publication types

Review