The Emergence of SARS-CoV-2 Variants With a Lower Antibody Response: A Genomic and Clinical Perspective

Suvro Biswas; Shafi Mahmud; Mohasana Akter Mita; Shamima Afrose; Md Robiul Hasan; Gobindo Kumar Paul; Mst Sharmin Sultana Shimu; Md Salah Uddin; Shahriar Zaman; Moon Nyeo Park; Abolghasem Siyadatpanah; Ahmad J Obaidullah; Md Abu Saleh; Jesus Simal-Gandara; Bonglee Kim

doi:10.3389/fmed.2022.825245

The Emergence of SARS-CoV-2 Variants With a Lower Antibody Response: A Genomic and Clinical Perspective

Front Med (Lausanne). 2022 May 6:9:825245. doi: 10.3389/fmed.2022.825245. eCollection 2022.

Authors

Affiliations

¹ Miocrobiology Laboratory, Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.
² Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, Bangladesh.
³ Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
⁴ Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, Iran.
⁵ Drug Exploration and Development Chair (DEDC), Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
⁶ Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, University of Vigo, Ourense, Spain.

Abstract

The emergence of several novel SARS-CoV-2 variants regarded as variants of concern (VOCs) has exacerbated pathogenic and immunologic prominences, as well as reduced diagnostic sensitivity due to phenotype modification-capable mutations. Furthermore, latent and more virulent strains that have arisen as a result of unique mutations with increased evolutionary potential represent a threat to vaccine effectiveness in terms of incoming and existing variants. As a result, resisting natural immunity, which leads to higher reinfection rates, and avoiding vaccination-induced immunization, which leads to a lack of vaccine effectiveness, has become a crucial problem for public health around the world. This study attempts to review the genomic variation and pandemic impact of emerging variations of concern based on clinical characteristics management and immunization effectiveness. The goal of this study is to gain a better understanding of the link between genome level polymorphism, clinical symptom manifestation, and current vaccination in the instance of VOCs.

Keywords: SARS-CoV-2; antibody; clinical perspective; genomic variation; variant of concern.

Publication types

Review