Abstract
Platinum(IV) chloride complexes with heterocyclic ligands have been prepared and characterized by infrared and electronic spectra. The compounds are of general formula Pt(L)nCl4, where L = N-ethylimidazole, N-propylimidazole, isoxazole, 3,5-dimethylisoxazole, benzoxazole, 2-methylbenzoxazole, 2,5-dimethylbenzoxazole, ethylenediamine, n = 2, 4, and also Pt(enEt2)3Cl4 X 2H2O, where enEt2 = N,N-diethylethylenediamine. These complexes are hexacoordinate with cis or trans configuration. The antitumoral activity of some complexes in mice inoculated with leukemia L1210 is reported.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Ethylenediamines / chemical synthesis*
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Ethylenediamines / therapeutic use
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Imidazoles / chemical synthesis*
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Imidazoles / therapeutic use
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Indicators and Reagents
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Isoxazoles / chemical synthesis*
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Isoxazoles / therapeutic use
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Leukemia L1210 / drug therapy
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Male
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Mice
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Organoplatinum Compounds / chemical synthesis*
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Organoplatinum Compounds / therapeutic use
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Oxazoles / chemical synthesis*
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Oxazoles / therapeutic use
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Spectrophotometry
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Ethylenediamines
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Imidazoles
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Indicators and Reagents
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Isoxazoles
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Organoplatinum Compounds
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Oxazoles