Platinum(IV) chloride complexes with heterocyclic ligands

J Inorg Biochem. 1987 Feb;29(2):95-100. doi: 10.1016/0162-0134(87)80016-8.

Abstract

Platinum(IV) chloride complexes with heterocyclic ligands have been prepared and characterized by infrared and electronic spectra. The compounds are of general formula Pt(L)nCl4, where L = N-ethylimidazole, N-propylimidazole, isoxazole, 3,5-dimethylisoxazole, benzoxazole, 2-methylbenzoxazole, 2,5-dimethylbenzoxazole, ethylenediamine, n = 2, 4, and also Pt(enEt2)3Cl4 X 2H2O, where enEt2 = N,N-diethylethylenediamine. These complexes are hexacoordinate with cis or trans configuration. The antitumoral activity of some complexes in mice inoculated with leukemia L1210 is reported.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Ethylenediamines / chemical synthesis*
  • Ethylenediamines / therapeutic use
  • Imidazoles / chemical synthesis*
  • Imidazoles / therapeutic use
  • Indicators and Reagents
  • Isoxazoles / chemical synthesis*
  • Isoxazoles / therapeutic use
  • Leukemia L1210 / drug therapy
  • Male
  • Mice
  • Organoplatinum Compounds / chemical synthesis*
  • Organoplatinum Compounds / therapeutic use
  • Oxazoles / chemical synthesis*
  • Oxazoles / therapeutic use
  • Spectrophotometry
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Ethylenediamines
  • Imidazoles
  • Indicators and Reagents
  • Isoxazoles
  • Organoplatinum Compounds
  • Oxazoles