A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules

Shi-Jun Yin; Guo-Can Zheng; Xin Yi; Guang-Ping Lv; Feng-Qing Yang

doi:10.1039/d2cc02206k

A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules

Chem Commun (Camb). 2022 Jun 9;58(47):6701-6704. doi: 10.1039/d2cc02206k.

Authors

Shi-Jun Yin¹, Guo-Can Zheng², Xin Yi³, Guang-Ping Lv³, Feng-Qing Yang¹

Affiliations

¹ Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China. fengqingyang@cqu.edu.cn.
² Analytical and Testing Center, Chongqing University, Chongqing 401331, China.
³ School of Food Science and Pharmaceutical Engineering, Nanjing Normal University, Nanjing 210023, China.

PMID: 35593409
DOI: 10.1039/d2cc02206k

Abstract

A novel MOF@HOF composite that can serve as a matrix for analysis of small molecules by MALDI-TOF-MS was fabricated through a simple solvothermal method. Taking falvonoids as an example, this composite/matrix presents high desorption/ionization efficiency, low background interference, high salt tolerance, and satisfactory signal reproducibility for MALDI-TOF-MS analysis.

MeSH terms

Hydrogen
Metal-Organic Frameworks*
Reproducibility of Results
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods

Substances

Metal-Organic Frameworks
Hydrogen